This family contains only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, besides histone, quite a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and parts of the TATA binding protein (TBP) complicated, TBP-related components TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Okay (target lysine is bold), can also be acknowledged by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of these substrates 17 , ninety four Therefore KMT7/KDM1A has emerged as a traditional model for dynamic lysine methylation of each histone and non-histone proteins.

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The members of the SUV39 family mentioned above are involved in each euchromatin and heterochromatin, however one other member of the identical household, G9a, is the predominant histone H3 K9 methyltransferase in mammalian euchromatin 14 There are two isoforms of G9a in the mouse: the quick kind (GenBank accession number NP_671493 ) corresponds to human G9a and the long form ( NP_665829 ), which lacks intron one, has additional Arg-Gly repeats on the amino terminus.

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